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camaro inherited one copy of the variant we tested
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Changes to this dog’s profile
- On 9/6/2022 changed name from "yellow girl" to "camaro"
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Health Summary
camaro is at increased risk for three genetic health conditions.
And inherited one variant that you should learn more about.
Von Willebrand Disease Type I, Type I vWD
How to interpret this result
camaro has one copy of this variant in the VWF gene and will likely have decreased levels of vWF compared to a dog without this variant. However, they will have higher levels of vWF than a dog with two copies of this variant. There is a slightly increased risk of bleeding in dogs with one copy of the variant, particularly when other clotting issues are also present. Please consult your veterinarian for further diagnostic and care options.
What is Von Willebrand Disease Type I, Type I vWD?
Von Willebrand Disease (vWD) is a type of coagulopathy, a disorder of blood clotting. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal multimer composition, and variable clinical signs.
Dilated Cardiomyopathy, DCM1
camaro inherited one copy of the variant we tested
How to interpret this result
camaro has one copy of a variant in the PDK4 gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM1, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks camaro shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for camaro.
What is Dilated Cardiomyopathy, DCM1?
DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.
Dilated Cardiomyopathy, DCM2
camaro inherited one copy of the variant we tested
How to interpret this result
camaro has one copy of a variant in the TTN gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM2, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks camaro shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for camaro.
What is Dilated Cardiomyopathy, DCM2?
DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.
ALT Activity
camaro inherited one copy of the variant we tested
Why is this important to your vet?
camaro has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that camaro has this genotype, as ALT is often used as an indicator of liver health and camaro is likely to have a lower than average resting ALT activity. As such, an increase in camaro’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.
Breed-Relevant Genetic Conditions
4 variants not detected
Deafness and Vestibular Syndrome of Dobermans, DVDob, DINGS (MYO7A)
Identified in Doberman Pinschers
Variant not detected
Unilateral Deafness and Vestibular Syndrome (PTPRQ Exon 39, Doberman Pinscher)
Identified in Doberman Pinschers
Variant not detected
Narcolepsy (HCRTR2 Intron 4, Doberman Pinscher Variant)
Identified in Doberman Pinschers
Variant not detected
Ehlers Danlos (ADAMTS2, Doberman Pinscher Variant)
Identified in Doberman Pinschers
Variant not detected
Additional Genetic Conditions
234 variants not detected
