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Toffee

Cockapoo

No bio has been provided yet

This dog has been viewed and been given 22 wags

Genetic Breed Result

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Poodle (Small)

A highly intelligent and playful dog, Miniature and Toy Poodles make for great lap dogs and companions.

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Cocker Spaniel

Cocker Spaniels are handsome and intelligent hunting dogs that are also well-suited to life as a loving family pet.

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DNA Breed Origins

Breed colors:
Poodle (Small)
Cocker Spaniel

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Changes to this dog’s profile
  • On 7/25/2022 changed name from "Kahlua" to "Toffee"
  • On 7/25/2022 changed name from "Toffee" to "Kahlua"
  • On 12/30/2021 changed name from "Dasher" to "Toffee"
  • On 12/26/2021 changed name from "Toffee" to "Dasher"
  • On 12/26/2021 changed name from "Dasher" to "Toffee"
  • On 12/26/2021 changed name from "Toffee" to "Dasher"
Here’s what Toffee’s family tree may have looked like.
While there may be other possible configurations of her family’s relationships, this is the most likely family tree to explain Toffee’s breed mix.

Breed Reveal Video

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Health Summary

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Toffee is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Toffee inherited both copies of the variant we tested

How to interpret this result

Toffee has two copies of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Toffee inherited one copy of the variant we tested

Why is this important to your vet?

Toffee has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Toffee has this genotype, as ALT is often used as an indicator of liver health and Toffee is likely to have a lower than average resting ALT activity. As such, an increase in Toffee’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD (VWF)

Identified in Small Poodles

Progressive Retinal Atrophy, prcd (PRCD Exon 1)

Identified in Cocker Spaniels and Small Poodles

Familial Nephropathy (COL4A4 Exon 3, Cocker Spaniel Variant)

Identified in Cocker Spaniels

Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM, Whippet and English Springer Spaniel Variant)

Identified in Cocker Spaniels

GM2 Gangliosidosis (HEXB, Poodle Variant)

Identified in Small Poodles

Neonatal Encephalopathy with Seizures, NEWS (ATF2)

Identified in Small Poodles

Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)

Identified in Cocker Spaniels

Exercise-Induced Collapse, EIC (DNM1)

Identified in Cocker Spaniels

Osteochondrodysplasia (SLC13A1, Poodle Variant)

Identified in Small Poodles

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Toffee’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A361/409/611

Map

A1b

Toffee’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A361/409/611

Toffee’s Haplotype

Part of the A1b haplogroup, this haplotype occurs most frequently in German Shepherd Dogs, Poodles, and Shiloh Shepherds.

A1b is the most common haplogroup found in German Shepherds.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Toffee inherited from her mom and dad? Check out her breed breakdown and family tree.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Toffee is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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