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“Chaos”
Tally Ho Major Chaos

Mixed Ancestry

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Registration

Continental Kennel Club (CKC): DM-05254933

Genetic Breed Result

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Dalmatian

Best known as the star of Disney’s 101 Dalmatians, this sleek and athletic dog breed has a history that goes back several hundred years. He started out as a coach dog but has also served in many other capacities, including hunter, firehouse dog, and circus performer. As charming in life as in film, he goes from gallant to goofy to gallant again in the blink of an eye, and loves to be a part of everything his family does.

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German Shorthaired Pointer

German Shorthaired Pointers are highly intelligent and energetic hunting dogs, while being a very friendly and willing companion.

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DNA Breed Origins

Breed colors:
Dalmatian
German Shorthaired Pointer

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Health Summary

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Chaos inherited one variant that you should learn more about.

And one variant that you should tell your vet about.

Urate Kidney & Bladder Stones

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Chaos inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Chaos’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Chaos is unlikely to develop this condition due to this variant because he only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Urate Kidney & Bladder Stones?

This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.

ALT Activity

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Chaos inherited both copies of the variant we tested

Why is this important to your vet?

Chaos has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Chaos's ALT activity above their current, healthy, ALT activity. As an increase above Chaos’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type II, Type II vWD (VWF, Pointer Variant)

Identified in German Shorthaired Pointers

Day Blindness (CNGB3 Exon 6, German Shorthaired Pointer Variant)

Identified in German Shorthaired Pointers

Neuronal Ceroid Lipofuscinosis 8, NCL 8 (CLN8, Australian Shepherd Variant)

Identified in German Shorthaired Pointers

Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)

Identified in German Shorthaired Pointers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Chaos’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A388

Map

A1a

Tally Ho Major Chaos’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A388

Tally Ho Major Chaos’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in Staffordshire Terriers, Labrador Retrievers, and English Bulldogs.

Shar Pei dogs think A1a is the coolest!

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Through Chaos’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

H1a.53

Map

A1a

Tally Ho Major Chaos’s Haplogroup

Some of the wolves that became the original dogs in Central Asia around 15,000 years ago came from this long and distinguished line of male dogs. After domestication, they followed their humans from Asia to Europe and then didn't stop there. They took root in Europe, eventually becoming the dogs that founded the Vizsla breed 1,000 years ago. The Vizsla is a Central European hunting dog, and all male Vizslas descend from this line. During the Age of Exploration, like their owners, these pooches went by the philosophy, "Have sail, will travel!" From the windy plains of Patagonia to the snug and homey towns of the American Midwest, the beaches of a Pacific paradise, and the broad expanse of the Australian outback, these dogs followed their masters to the outposts of empires. Whether through good fortune or superior genetics, dogs from the A1a lineage traveled the globe and took root across the world. Now you find village dogs from this line frolicking on Polynesian beaches, hanging out in villages across the Americas, and scavenging throughout Old World settlements. You can also find this "prince of patrilineages" in breeds as different as German Shepherds, Golden Retrievers, Pugs, Border Collies, Scottish Terriers, and Irish Wolfhounds. No male wolf line has been as successful as the A1a line!

H1a.53

Tally Ho Major Chaos’s Haplotype

Part of the A1a haplogroup, this haplotype occurs most frequently in Golden Retrievers, Border Collies, and the Coton de Tulear.

Dogs with A1a lineage travelled during European Colonial times.

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