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“Senna”
Senna

Mixed Ancestry

“Werkelijk een fantastische hond met een briljant lief karakter”

Place of Birth

Bornerbroek, Overijssel, Nederland

Current Location

Putten, Gelderland, Nederland

From

Bornerbroek, Overijssel, Nederland

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Genetic Breed Result

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Stabyhoun

Renowned for its peaceful disposition, the Stabyhoun is a soft-mouthed retriever, a fine pointer, excellent tracker, and a good watchdog.

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Rat Terrier

The Rat Terrier is an American dog breed with a background as a farm dog and hunting companion.

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Wetterhoun

This rare breed from the Netherlands is traditionally used to hunt small mammals and waterfowl. Wetterhouns love being in the water; they have a curly, greasy waterproof coat.

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DNA Breed Origins

Breed colors:
Stabyhoun
Rat Terrier
Wetterhoun

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Health Summary

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Senna is at increased risk for one genetic health condition.

And inherited three variants that you should learn more about.

Von Willebrand Disease Type I, Type I vWD

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Senna inherited one copy of the variant we tested

How to interpret this result

Senna has one copy of this variant in the VWF gene and will likely have decreased levels of vWF compared to a dog without this variant. However, they will have higher levels of vWF than a dog with two copies of this variant. There is a slightly increased risk of bleeding in dogs with one copy of the variant, particularly when other clotting issues are also present. Please consult your veterinarian for further diagnostic and care options.

What is Von Willebrand Disease Type I, Type I vWD?

Von Willebrand Disease (vWD) is a type of coagulopathy, a disorder of blood clotting. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal multimer composition, and variable clinical signs.

Protein Losing Nephropathy, PLN

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Senna inherited one copy of the variant we tested

What does this result mean?

We do not know whether this increases the risk that Senna will develop Protein Losing Nephropathy, PLN.

Scientific Basis

Research studies for this variant have been based on dogs of other breeds. Not enough dogs with Senna's breed have been studied to know whether or not this variant will increase Senna's risk of developing this disease.

Impact on Breeding

Research into the clinical impact of this variant is ongoing. We recommend tracking this genetic result and incidence of Protein Losing Nephropathy, PLN in your breeding program and related dogs.

What is Protein Losing Nephropathy, PLN?

Protein Losing Nephropathy causes inappropriate loss of protein in the urine. Certain parts of the kidney act as a sieve where ions, small molecules like urea, and water are filtered out of the blood into the urine. In PLN, the sieve is compromised and protein moves in the urine. This leads to muscle wasting, abnormal fluid accumulation in the skin and limbs, and kidney failure.

Degenerative Myelopathy, DM

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Senna inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Senna’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Senna is unlikely to develop this condition due to this variant because she only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of her offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Degenerative Myelopathy, DM?

The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.

ALT Activity

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Senna inherited one copy of the variant we tested

Why is this important to your vet?

Senna has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Senna has this genotype, as ALT is often used as an indicator of liver health and Senna is likely to have a lower than average resting ALT activity. As such, an increase in Senna’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Congenital Hypothyroidism (TPO, Rat, Toy, Hairless Terrier Variant)

Identified in Rat Terriers

Severe Combined Immunodeficiency, SCID (RAG1, Wetterhoun Variant)

Identified in Wetterhouns

Primary Lens Luxation (ADAMTS17)

Identified in Rat Terriers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Senna’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

B1

Haplotype

B1c

Map

B1

Senna’s Haplogroup

B1 is the second most common maternal lineage in breeds of European or American origin. It is the female line of the majority of Golden Retrievers, Basset Hounds, and Shih Tzus, and about half of Beagles, Pekingese and Toy Poodles. This lineage is also somewhat common among village dogs that carry distinct ancestry from these breeds. We know this is a result of B1 dogs being common amongst the European dogs that their conquering owners brought around the world, because nowhere on earth is it a very common lineage in village dogs. It even enables us to trace the path of (human) colonization: Because most Bichons are B1 and Bichons are popular in Spanish culture, B1 is now fairly common among village dogs in Latin America.

B1c

Senna’s Haplotype

Part of the large B1 haplogroup, we have detected this haplotype in Mexico and Lebanon village dogs. Among the 12 breeds that we have spotted this haplotype in, it occurs most frequently in Border Collies, Australian Shepherd Dogs, and West Highland white Terriers.

The B1 haplogroup can be found in village dogs like the Peruvian Village Dog, pictured above.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Senna inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Senna is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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