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“Piper”
Piper

English Springer Spaniel

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Registration

American Kennel Club (AKC):
Microchip: 956000013806426

Genetic Breed Result

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English Springer Spaniel

English Springer Spaniels are an energetic and loyal companion dog, bred for hunting but also popular among families.

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Health Summary

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Piper has one variant that you should let your vet know about.

ALT Activity

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Piper inherited one copy of the variant we tested

Why is this important to your vet?

Piper has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Piper has this genotype, as ALT is often used as an indicator of liver health and Piper is likely to have a lower than average resting ALT activity. As such, an increase in Piper’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)

Identified in English Springer Spaniels

Familial Nephropathy (COL4A4 Exon 30, English Springer Spaniel Variant)

Identified in English Springer Spaniels

Canine Fucosidosis (FUCA1)

Identified in English Springer Spaniels

Glycogen storage disease Type VII, Phosphofructokinase Deficiency, PFK Deficiency (PFKM, Whippet and English Springer Spaniel Variant)

Identified in English Springer Spaniels

Degenerative Myelopathy, DM (SOD1A)

Identified in English Springer Spaniels

Shaking Puppy Syndrome (PLP1, English Springer Spaniel Variant)

Identified in English Springer Spaniels

Acral Mutilation Syndrome (GDNF-AS, Spaniel and Pointer Variant)

Identified in English Springer Spaniels

Long QT Syndrome (KCNQ1)

Identified in English Springer Spaniels

Intervertebral Disc Disease (Type I) (FGF4 retrogene - CFA12)

Identified in English Springer Spaniels

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Piper’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

C1

Haplotype

C39

Map

C1

Piper’s Haplogroup

Congratulations, C1 is a very exotic female lineage! It is more closely associated with maternal lineages found in wolves, foxes and jackals than with other dog lineages. So it seems dogs in this group have a common male dog ancestor who, many thousands of years ago, mated with a female wolf! This is not a common lineage in any breed, though a good number of German Shepherds and Doberman Pinchers are C1. It is also found in breeds as diverse as Peruvian Inca Orchids and Pekingese; it is rarely found amongst Labrador Retrievers, Border Collies, Siberian Huskies, or Cocker Spaniels. Despite its fascinating origins, it is widely distributed around the globe, and even shows up frequently among Peruvian village dogs. It almost certainly survived at low frequency in Europe for millennia and then was dispersed outside of Europe by colonialism, though not as successfully as some other lineages.

C39

Piper’s Haplotype

Part of the C1 haplogroup, this haplotype occurs most frequently in Pomerianians and Xoloitzcuintli.

The C1 maternal line is commonly found in Jackals.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Piper inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Piper is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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