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Denalli's Wild Margarita inherited one copy of the variant we tested
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Changes to this dog’s profile
- On 8/31/2023 changed name from "pink puppy" to "Denalli's Wild Margarita"
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Health Summary
Denalli's Wild Margarita is at increased risk for two genetic health conditions.
Dilated Cardiomyopathy, DCM1
How to interpret this result
Denalli's Wild Margarita has one copy of a variant in the PDK4 gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM1, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Denalli's Wild Margarita shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Denalli's Wild Margarita.
What is Dilated Cardiomyopathy, DCM1?
DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.
Dilated Cardiomyopathy, DCM2
Denalli's Wild Margarita inherited both copies of the variant we tested
How to interpret this result
Denalli's Wild Margarita has two copies of a variant in TTN gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM2, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Denalli's Wild Margarita shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Denalli's Wild Margarita.
What is Dilated Cardiomyopathy, DCM2?
DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.
Breed-Relevant Genetic Conditions
5 variants not detected
Von Willebrand Disease Type I, Type I vWD (VWF)
Identified in Doberman Pinschers
Variant not detected
Deafness and Vestibular Syndrome of Dobermans, DVDob, DINGS (MYO7A)
Identified in Doberman Pinschers
Variant not detected
Unilateral Deafness and Vestibular Syndrome (PTPRQ Exon 39, Doberman Pinscher)
Identified in Doberman Pinschers
Variant not detected
Narcolepsy (HCRTR2 Intron 4, Doberman Pinscher Variant)
Identified in Doberman Pinschers
Variant not detected
Ehlers Danlos (ADAMTS2, Doberman Pinscher Variant)
Identified in Doberman Pinschers
Variant not detected
Additional Genetic Conditions
247 variants not detected
