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“Bentley”
Birkline's Bentley Raymond

Doberman Pinscher

“Heracles”

Place of Birth

Humble, TX, USA

Current Location

Houston, Texas, USA

From

Birkline Dobermans, Will Clayton Parkway, Humble, TX, USA

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Registration

American Kennel Club (AKC): WS6951848
Microchip: 93300032094858

Genetic Breed Result

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Doberman Pinscher

Doberman Pinschers are a strong and athletic breed that are built to guard and protect.

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Changes to this dog’s profile
  • On 2/19/2021 changed name from "Heracles - 20200830HQB" to "Birkline's Bentley Raymond"
  • On 9/17/2020 changed name from "Heracles" to "Heracles - 20200830HQB"

Health Summary

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Bentley is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Dilated Cardiomyopathy, DCM2

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Bentley inherited one copy of the variant we tested

How to interpret this result

Bentley has one copy of a variant in the TTN gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM2, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Bentley shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Bentley.

What is Dilated Cardiomyopathy, DCM2?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

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Bentley inherited one copy of the variant we tested

Why is this important to your vet?

Bentley has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Bentley has this genotype, as ALT is often used as an indicator of liver health and Bentley is likely to have a lower than average resting ALT activity. As such, an increase in Bentley’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Von Willebrand Disease Type I, Type I vWD

Identified in Doberman Pinschers

Deafness and Vestibular Syndrome of Dobermans, DVDob, DINGS

Identified in Doberman Pinschers

Dilated Cardiomyopathy, DCM1

Identified in Doberman Pinschers

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Base Coat Color

Base Coat Color

Coat Color Modifiers

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Through Bentley’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

A408

Map

A1b

Birkline's Bentley Raymond’s Haplogroup

This female lineage was very likely one of the original lineages in the wolves that were first domesticated into dogs in Central Asia about 15,000 years ago. Since then, the lineage has been very successful and travelled the globe! Dogs from this group are found in ancient Bronze Age fossils in the Middle East and southern Europe. By the end of the Bronze Age, it became exceedingly common in Europe. These dogs later became many of the dogs that started some of today's most popular breeds, like German Shepherds, Pugs, Whippets, English Sheepdogs and Miniature Schnauzers. During the period of European colonization, the lineage became even more widespread as European dogs followed their owners to far-flung places like South America and Oceania. It's now found in many popular breeds as well as village dogs across the world!

A408

Birkline's Bentley Raymond’s Haplotype

Part of the A1b haplogroup, the A408 haplotype occurs most commonly in Doberman Pinschers. It's a rare find!

A1b is the most common haplogroup found in German Shepherds.

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Through Bentley’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

Ha.13

Map

A1b

Birkline's Bentley Raymond’s Haplogroup

For most of dog history, this haplogroup was probably quite rare. However, a couple hundred years ago it seems to have found its way into a prized male guard dog in Europe who had many offspring, including the ancestors of many European guard breeds such as Doberman Pinchers, St. Bernards, and Great Danes. Despite being rare, many of the most imposing dogs on Earth have it; strangely, so do many Pomeranians! Perhaps this explains why some Poms are so tough, acting like they're ten times their actual size! This lineage is most commonly found in working dogs, in particular guard dogs. With origins in Europe, it spread widely across other regions as Europeans took their dogs across the world.

Ha.13

Birkline's Bentley Raymond’s Haplotype

Part of the A1b haplogroup, this haplotype occurs most frequently in Doberman Pinschers.

Great Danes and Pomeranians have this in common!

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