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“IROC”
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Summary
Health

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Place of Birth

USA

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Registration

American Kennel Club (AKC): WS76494702

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Health

Health Summary

IROC is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Dilated Cardiomyopathy, DCM2

IROC inherited one copy of the variant we tested

How to interpret this result

IROC has one copy of a variant in the TTN gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM2, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks IROC shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for IROC.

What is Dilated Cardiomyopathy, DCM2?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

IROC inherited one copy of the variant we tested

Why is this important to your vet?

IROC has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that IROC has this genotype, as ALT is often used as an indicator of liver health and IROC is likely to have a lower than average resting ALT activity. As such, an increase in IROC’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.