Comet inherited both copies of the variant we tested
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“He is the son of Gibson and Nora”
Place of Birth
Salem, MO, USA
Current Location
Salem, MO, USA
From
Salem, MO, USA
This dog has been viewed and been given 0 wags
Registration
American Kennel Club
(AKC):
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Changes to this dog’s profile
- On 12/4/2021 changed handle from "orange148" to "comet1482"
- On 12/4/2021 changed name from "Green" to "Comet"
- On 10/27/2021 changed name from "Orange" to "Green"
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Health Summary
Comet is at increased risk for one genetic health condition.
And inherited one variant that you should learn more about.
Urate Kidney & Bladder Stones
How to interpret this result
Comet has two copies of a variant in the SLC2A9 gene and is at risk for developing HUU. If you notice Comet straining to urinate, producing urine tinged with blood, or not producing any urine at all, please seek veterinary care immediately; these are signs of urinary obstruction secondary to urolithiasis and could be life threatening.
What is Urate Kidney & Bladder Stones?
This condition causes kidney and bladder stones composed of urate. In most dogs, uric acid is converted to allantoin, an inert substance that is then excreted in the urine. Dogs with HUU have defects in the pathway that converts uric acid to allantoin. As such, uric acid builds up, crystallizes and forms urate stones in the kidney and bladder. Uric acid is an intermediate of purine metabolism. While hyperuricemia in other species (including humans) can lead to painful conditions such as gout, dogs do not develop systemic signs of hyperuricemia.
ALT Activity
Comet inherited both copies of the variant we tested
Why is this important to your vet?
Comet has two copies of a variant in the GPT gene and is likely to have a lower than average baseline ALT activity. ALT is a commonly used measure of liver health on routine veterinary blood chemistry panels. As such, your veterinarian may want to watch for changes in Comet's ALT activity above their current, healthy, ALT activity. As an increase above Comet’s baseline ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.
What is ALT Activity?
Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.