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Clio van de Peelhelden

Dachshund

No bio has been provided yet

Instagram tag
@https://instagram.com/vandepeelhelden?igshid=NGExMmI2YTkyZg==

Place of Birth

Panningen, Limburg, Nederland

Current Location

Panningen, Limburg, Nederland

From

Panningen, Limburg, Nederland

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Registration

Fédération Cynologique Internationale (FCI): NHSB: 3293042
Microchip: 528140000894227

Genetic Breed Result

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Dachshund

The Dachshund, meaning “badger dog” in German, is a lively breed with a friendly personality and a great sense of smell. Known for their long and low bodies, they are spirited hunters that excel in both above and below-ground work. They come in three different coat varieties (smooth, wirehaired or longhaired) and can be miniature or standard size.

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Health Summary

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Clio van de Peelhelden is at increased risk for one genetic health condition.

And inherited one variant that you should learn more about.

Intervertebral Disc Disease (Type I)

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Clio van de Peelhelden inherited both copies of the variant we tested

How to interpret this result

Clio van de Peelhelden has two copies of an FGF4 retrogene on chromosome 12. In some breeds such as Beagles, Cocker Spaniels, and Dachshunds (among others) this variant is found in nearly all dogs. While those breeds are known to have an elevated risk of IVDD, many dogs in those breeds never develop IVDD. For mixed breed dogs and purebreds of other breeds where this variant is not as common, risk for Type I IVDD is greater for individuals with this variant than for similar dogs.

What is Intervertebral Disc Disease (Type I)?

Type I Intervertebral Disc Disease (IVDD) is a back/spine issue that refers to a health condition affecting the discs that act as cushions between vertebrae. With Type I IVDD, affected dogs can have a disc event where it ruptures or herniates towards the spinal cord. This pressure on the spinal cord causes neurologic signs which can range from a wobbly gait to impairment of movement. Chondrodystrophy (CDDY) refers to the relative proportion between a dog’s legs and body, wherein the legs are shorter and the body longer. There are multiple different variants that can cause a markedly chondrodystrophic appearance as observed in Dachshunds and Corgis. However, this particular variant is the only one known to also increase the risk for IVDD.

ALT Activity

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Clio van de Peelhelden inherited one copy of the variant we tested

Why is this important to your vet?

Clio van de Peelhelden has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Clio van de Peelhelden has this genotype, as ALT is often used as an indicator of liver health and Clio van de Peelhelden is likely to have a lower than average resting ALT activity. As such, an increase in Clio van de Peelhelden’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd4/cord1 (RPGRIP1)

Identified in Dachshunds

Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A, MPS IIIA (SGSH Exon 6, Dachshund Variant)

Identified in Dachshunds

Neuronal Ceroid Lipofuscinosis 1, NCL 1 (PPT1 Exon 8, Dachshund Variant 1)

Identified in Dachshunds

Neuronal Ceroid Lipofuscinosis 2, NCL 2 (TPP1 Exon 4, Dachshund Variant 2)

Identified in Dachshunds

Narcolepsy (HCRTR2 Exon 1, Dachshund Variant)

Identified in Dachshunds

Osteogenesis Imperfecta (SERPINH1, Dachshund Variant)

Identified in Dachshunds

Limb-Girdle Muscular Dystrophy 2D (SGCA Exon 3, Miniature Dachshund Variant)

Identified in Dachshunds

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

Performance

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Through Clio van de Peelhelden’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below the map.

Haplogroup

C1

Haplotype

C36

Map

C1

Clio van de Peelhelden’s Haplogroup

Congratulations, C1 is a very exotic female lineage! It is more closely associated with maternal lineages found in wolves, foxes and jackals than with other dog lineages. So it seems dogs in this group have a common male dog ancestor who, many thousands of years ago, mated with a female wolf! This is not a common lineage in any breed, though a good number of German Shepherds and Doberman Pinchers are C1. It is also found in breeds as diverse as Peruvian Inca Orchids and Pekingese; it is rarely found amongst Labrador Retrievers, Border Collies, Siberian Huskies, or Cocker Spaniels. Despite its fascinating origins, it is widely distributed around the globe, and even shows up frequently among Peruvian village dogs. It almost certainly survived at low frequency in Europe for millennia and then was dispersed outside of Europe by colonialism, though not as successfully as some other lineages.

C36

Clio van de Peelhelden’s Haplotype

Part of the C1 haplogroup, the C36 haplotype occurs most commonly in Karelian Bear Dogs, West Highland White Terriers and Portuguese Water Dogs.

The C1 maternal line is commonly found in Jackals.

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The Paternal Haplotype reveals a dog’s deep ancestral lineage, stretching back thousands of years to the original domestication of dogs.

Are you looking for information on the breeds that Clio van de Peelhelden inherited from her mom and dad? Check out her breed breakdown.

Paternal Haplotype is determined by looking at a dog’s Y-chromosome—but not all dogs have Y-chromosomes!

Why can’t we show Paternal Haplotype results for female dogs?

All dogs have two sex chromosomes. Female dogs have two X-chromosomes (XX) and male dogs have one X-chromosome and one Y-chromosome (XY). When having offspring, female (XX) dogs always pass an X-chromosome to their puppy. Male (XY) dogs can pass either an X or a Y-chromosome—if the puppy receives an X-chromosome from its father then it will be a female (XX) puppy and if it receives a Y-chromosome then it will be a male (XY) puppy. As you can see, Y-chromosomes are passed down from a male dog only to its male offspring.

Since Clio van de Peelhelden is a female (XX) dog, she has no Y-chromosome for us to analyze and determine a paternal haplotype.

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