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Ch Goldgrove I’ll Have Another

Doberman Pinscher

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Registration

American Kennel Club (AKC): WS41153208

Genetic Breed Result

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Doberman Pinscher

Doberman Pinschers are a strong and athletic breed that are built to guard and protect.

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Here’s what Ch Goldgrove I’ll Have Another’s family tree may have looked like.
While there may be other possible configurations of his family’s relationships, this is the most likely family tree to explain Ch Goldgrove I’ll Have Another’s breed mix.
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Health Summary

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Ch Goldgrove I’ll Have Another is at increased risk for three genetic health conditions.

And inherited one variant that you should learn more about.

Von Willebrand Disease Type I, Type I vWD

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Ch Goldgrove I’ll Have Another inherited one copy of the variant we tested

How to interpret this result

Ch Goldgrove I’ll Have Another has one copy of this variant in the VWF gene and will likely have decreased levels of vWF compared to a dog without this variant. However, they will have higher levels of vWF than a dog with two copies of this variant. There is a slightly increased risk of bleeding in dogs with one copy of the variant, particularly when other clotting issues are also present. Please consult your veterinarian for further diagnostic and care options.

What is Von Willebrand Disease Type I, Type I vWD?

Von Willebrand Disease (vWD) is a type of coagulopathy, a disorder of blood clotting. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal multimer composition, and variable clinical signs.

Dilated Cardiomyopathy, DCM1

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Ch Goldgrove I’ll Have Another inherited one copy of the variant we tested

How to interpret this result

Ch Goldgrove I’ll Have Another has one copy of a variant in the PDK4 gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM1, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Ch Goldgrove I’ll Have Another shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Ch Goldgrove I’ll Have Another.

What is Dilated Cardiomyopathy, DCM1?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

Dilated Cardiomyopathy, DCM2

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Ch Goldgrove I’ll Have Another inherited one copy of the variant we tested

How to interpret this result

Ch Goldgrove I’ll Have Another has one copy of a variant in the TTN gene associated with increased risk for DCM in the American Doberman Pinscher. This variant, also referred to as DCM2, is inherited in a dominant manner, meaning having one or two copies of this variant is thought to confer the same amount of risk. However, the variant is thought to have incomplete penetrance: That is, not all dogs with this variant will ultimately show signs of DCM. Moreover, the impact of this variant in other breeds of dog besides the Doberman has yet to be fully understood. However, if your veterinarian thinks Ch Goldgrove I’ll Have Another shows signs of having DCM based on their diagnostic testing, you now have the opportunity to discuss early treatment. Please consult with your veterinarian regarding a diagnostic and treatment plan for Ch Goldgrove I’ll Have Another.

What is Dilated Cardiomyopathy, DCM2?

DCM is the most common acquired heart disease of adult dogs. The heart has two heavily muscled ventricles that pump blood away from the heart. This disease causes progressive weakening of the ventricles by reducing the muscle mass, which causes the ventricles to dilate. Dilated ventricles do not contract and circulate oxygenated blood well, which eventually leads to heart failure.

ALT Activity

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Ch Goldgrove I’ll Have Another inherited one copy of the variant we tested

Why is this important to your vet?

Ch Goldgrove I’ll Have Another has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. Please inform your veterinarian that Ch Goldgrove I’ll Have Another has this genotype, as ALT is often used as an indicator of liver health and Ch Goldgrove I’ll Have Another is likely to have a lower than average resting ALT activity. As such, an increase in Ch Goldgrove I’ll Have Another’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

What is ALT Activity?

Alanine aminotransferase (ALT) is a clinical tool that can be used by veterinarians to better monitor liver health. This result is not associated with liver disease. ALT is one of several values veterinarians measure on routine blood work to evaluate the liver. It is a naturally occurring enzyme located in liver cells that helps break down protein. When the liver is damaged or inflamed, ALT is released into the bloodstream.

Breed-Relevant Genetic Conditions

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Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Ch Goldgrove I’ll Have Another’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

C1

Haplotype

C25

Map

C1

Ch Goldgrove I’ll Have Another’s Haplogroup

Congratulations, C1 is a very exotic female lineage! It is more closely associated with maternal lineages found in wolves, foxes and jackals than with other dog lineages. So it seems dogs in this group have a common male dog ancestor who, many thousands of years ago, mated with a female wolf! This is not a common lineage in any breed, though a good number of German Shepherds and Doberman Pinchers are C1. It is also found in breeds as diverse as Peruvian Inca Orchids and Pekingese; it is rarely found amongst Labrador Retrievers, Border Collies, Siberian Huskies, or Cocker Spaniels. Despite its fascinating origins, it is widely distributed around the globe, and even shows up frequently among Peruvian village dogs. It almost certainly survived at low frequency in Europe for millennia and then was dispersed outside of Europe by colonialism, though not as successfully as some other lineages.

C25

Ch Goldgrove I’ll Have Another’s Haplotype

Part of the C1 haplogroup, this haplotype has been spotted in village dogs in Peru and Namibia. Among breeds, it occurs most frequently in Doberman Pinschers, but has also been detected in German Shepherd Dogs and Labrador Retrievers.

The C1 maternal line is commonly found in Jackals.

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Through Ch Goldgrove I’ll Have Another’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1b

Haplotype

Ha.3

Map

A1b

Ch Goldgrove I’ll Have Another’s Haplogroup

For most of dog history, this haplogroup was probably quite rare. However, a couple hundred years ago it seems to have found its way into a prized male guard dog in Europe who had many offspring, including the ancestors of many European guard breeds such as Doberman Pinchers, St. Bernards, and Great Danes. Despite being rare, many of the most imposing dogs on Earth have it; strangely, so do many Pomeranians! Perhaps this explains why some Poms are so tough, acting like they're ten times their actual size! This lineage is most commonly found in working dogs, in particular guard dogs. With origins in Europe, it spread widely across other regions as Europeans took their dogs across the world.

Ha.3

Ch Goldgrove I’ll Have Another’s Haplotype

Part of the A1b haplogroup, this haplotype is found in village dogs in Peru and the French Polynesian Islands. It is also common among Doberman Pinscher, Saint Bernard, and Rhodesian Ridgeback.

Great Danes and Pomeranians have this in common!

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