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“Buddy”
BlackWaters Buddy the King

Olde English Bulldogge

“He has the most beautiful ice blue eyes.”

Place of Birth

Texas, USA

Current Location

Colorado Springs, Colorado, USA

From

North Carolina, USA

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Registration

N/A :

Genetic Breed Result

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Olde English Bulldogge

Though its name is deceiving, the Olde English Bulldogge is a fairly young breed, developed by American breeders in the 1970s with the aim to recreate the original working bulldog from 19th century England.

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Health Summary

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Buddy inherited one variant that you should learn more about.

Canine Multifocal Retinopathy, cmr1

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Buddy inherited one copy of the variant we tested

What does this result mean?

This variant should not impact Buddy’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Buddy is unlikely to develop this condition due to this variant because he only has one copy of the variant.

Impact on Breeding

Your dog carries this variant and will pass it on to ~50% of his offspring. You can email breeders@embarkvet.com to discuss with a genetic counselor how the genotype results should be applied to a breeding program.

What is Canine Multifocal Retinopathy, cmr1?

This is a non-progressive retinal disease that, in rare cases, can lead to vision loss. Dogs with larger lesions can suffer from vision loss. CMR is fairly non-progressive; new lesions will typically stop forming by the time a dog is an adult, and some lesions will even regress with time.

Breed-Relevant Genetic Conditions

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Progressive Retinal Atrophy, crd1 (PDE6B, American Staffordshire Terrier Variant)

Identified in Olde English Bulldogges

Urate Kidney & Bladder Stones (SLC2A9)

Identified in Olde English Bulldogges

Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A (ARSG Exon 2, American Staffordshire Terrier Variant)

Identified in Olde English Bulldogges

Neuronal Ceroid Lipofuscinosis 10, NCL 10 (CTSD Exon 5, American Bulldog Variant)

Identified in Olde English Bulldogges

L-2-Hydroxyglutaricaciduria, L2HGA (L2HGDH, Staffordshire Bull Terrier Variant)

Identified in Olde English Bulldogges

Ichthyosis (NIPAL4, American Bulldog Variant)

Identified in Olde English Bulldogges

Additional Genetic Conditions

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Traits

Explore the genetics behind your dog’s appearance and size.

Coat Color

Coat Color

Other Coat Traits

Other Coat Traits

Other Body Features

Other Body Features

Body Size

Body Size

Performance

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Through Buddy’s mitochondrial DNA we can trace his mother’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

A1a

Haplotype

A388

Map

A1a

BlackWaters Buddy the King’s Haplogroup

A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar-Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism.

A388

BlackWaters Buddy the King’s Haplotype

Part of the large A1a haplogroup, this haplotype occurs most frequently in Staffordshire Terriers, Labrador Retrievers, and English Bulldogs.

Shar Pei dogs think A1a is the coolest!

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Through Buddy’s Y-chromosome we can trace his father’s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map.

Haplogroup

D

Haplotype

H7.1/6/7

Map

D

BlackWaters Buddy the King’s Haplogroup

The D paternal lineage is very common in well-known populations of dogs. Breeds belonging to the D lineage likely have direct male ancestors that can be traced all the way back to the origin of domestic dogs themselves! One popular breed that commonly sports a D lineage is the Boxer. Boxers were developed in the late 19th century from Mastiff dogs, so it is no surprise that D is well represented among Mastiffs, Bulldogs, as well as Terriers. Intriguingly, D is also found among Lhasa Apsos, an ancient Tibetan breed, and Afghan Hounds. While the presence of this lineage in Polynesia or the New World can be chalked up to interbreeding with European dogs brought during voyages of discovery or later settlement, D is also well represented among village dog populations in the Middle East and Africa. If the fact that we find dogs bearing a D lineage in the Middle East (not to mention the large amount of diversity among Middle Eastern D lineage males) is any indication of ancient residence in that region, then the presence among Oceanian village dogs is peculiar. Rather, it may be that D is part of a broader Eurasian group of ancient paternal lineages which disappeared from the eastern portion of its original range, persisting in the island of New Guinea as well as West Asia and Africa. With the rise of Mastiff breeds, the D lineage received a new life as it became common among many types of working dogs.

H7.1/6/7

BlackWaters Buddy the King’s Haplotype

Part of the D haplogroup, this haplotype occurs most frequently in mixed breed dogs.

The D paternal lineage is common in Boxers.

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